Genetic Subpopulations of Rift Valley Fever Virus Strains ZH548 and MP-12 and Recombinant MP-12 Strains
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چکیده
منابع مشابه
Characterization of Rift Valley Fever Virus MP-12 Strain Encoding NSs of Punta Toro Virus or Sandfly Fever Sicilian Virus
Rift Valley fever virus (RVFV; genus Phlebovirus, family Bunyaviridae) is a mosquito-borne zoonotic pathogen which can cause hemorrhagic fever, neurological disorders or blindness in humans, and a high rate of abortion in ruminants. MP-12 strain, a live-attenuated candidate vaccine, is attenuated in the M- and L-segments, but the S-segment retains the virulent phenotype. MP-12 was manufactured ...
متن کاملEvaluation of lamb and calf responses to Rift Valley fever MP-12 vaccination.
Rift Valley fever (RVF) is an important viral disease of animals and humans in Africa and the Middle East that is transmitted by mosquitoes. The disease is of concern to international agricultural and public health communities. The RVFV MP-12 strain has been the most safety tested attenuated vaccine strain; thus it is being considered as a potential vaccine for the US national veterinary stockp...
متن کاملRisk analysis of inter-species reassortment through a Rift Valley fever phlebovirus MP-12 vaccine strain
Rift Valley fever (RVF) is a mosquito-borne zoonotic disease endemic to Africa and the Arabian Peninsula. The causative agent, Rift Valley fever phlebovirus (RVFV), belongs to the genus Phlebovirus in the family Phenuiviridae and causes high rates of abortions in ruminants, and hemorrhagic fever, encephalitis, or blindness in humans. Viral maintenance by mosquito vectors has led to sporadic RVF...
متن کامل1 1 Rift Valley fever virus MP - 12 vaccine is fully attenuated by a combination of 2 partial attenuations in the S - , M - and L - segments 3 4
4 Tetsuro Ikegami,1,2,3* Terence E. Hill,1 Jennifer K. Smith,1,4 Lihong Zhang,1,4 Terry L. 5 Juelich,1,4 Bin Gong, 1,3,4 Olga A.L. Slack, 1† Hoai J. Ly, 1 Nandadeva Lokugamage, 1 6 Alexander N. Freiberg,1,2,3,4 7 8 Department of Pathology, The Sealy Center for Vaccine Development, The Center for 9 Biodefense and Emerging Infectious Diseases, Galveston National Laboratory, The 10 University of T...
متن کاملUsing reverse genetics to manipulate the NSs gene of the Rift Valley fever virus MP-12 strain to improve vaccine safety and efficacy.
Rift Valley fever virus (RVFV), which causes hemorrhagic fever, neurological disorders or blindness in humans, and a high rate abortion and fetal malformation in ruminants, has been classified as a HHS/USDA overlap select agent and a risk group 3 pathogen. It belongs to the genus Phlebovirus in the family Bunyaviridae and is one of the most virulent members of this family. Several reverse genet...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2012
ISSN: 0022-538X
DOI: 10.1128/jvi.02081-12